Clinical features

• Migratory superficial thrombophlebitis (recurrent): often seen prior to the onset of limb ischemia
  • Tender nodules along the course of the affected vein
• Raynaud phenomenon
• Chronic or acute limb ischemia: may progress from distal to proximal vessels
  • Intermittent claudication
  • Pain at rest, cool extremities, and/or diminished or absent pulses
  • Ulceration and/or gangrene of fingertips and/or toes (digits may autoamputate)