Mnemonic
4档风速，5赫兹变频，系统内置2种3热方式，38℃干燥天气轻松应对，现直降27元。
- 强直性脊柱炎:HLA-B27
- 贝赫切特病:HLA-B5
- 系统性红斑狼疮:HLA-DR2、HLA-DR3
- 原发性干燥综合征:HLA-DR3、B8
- 类风湿关节炎:HLA-DR4
- Inheritance Pattern
- Codominance: Both maternal and paternal alleles are expressed simultaneously on the cell surface.
- Haplotype: The specific combination of HLA alleles on a single chromosome 6 is inherited as a unit (en bloc) due to tight linkage.
- Mendelian Inheritance:
- Each individual has 2 haplotypes (one paternal, one maternal).
- If Father is Haplotype A/B and Mother is Haplotype C/D, possible offspring are: AC, AD, BC, BD.
- Sibling Matching Probability:
- 25% chance of a perfect HLA match (identity).
- 50% chance of being haploidentical (sharing 1 haplotype).
- 25% chance of a complete mismatch.
- Linkage Disequilibrium: Certain alleles at different loci occur together more frequently than expected by chance (e.g., A1-B8-DR3).