• Coronary Artery Disease (CAD)
    • Quality: Substernal pressure/heaviness.
    • Triggers: Precipitated by physical exertion or emotional stress.
    • Relieving Factors: Relieved by rest or Nitroglycerin (NTG).
    • High-Yield Note: Stable angina is predictable; Unstable Angina (UA)/NSTEMI/STEMI involves pain at rest or increasing frequency/intensity.
  • Pulmonary & Pleuritic (Pleurisy, Pneumonia, Pericarditis, PE)
    • Quality: Sharp, stabbing pain.
    • Triggers: Worse with inspiration (pleuritic) or coughing.
    • Pericarditis Specific: Positional pain; worse when lying flat, improved by leaning forward.
    • PE Specific: Often associated with sudden-onset SOB, tachycardia, and hypoxia.
  • Aortic (Dissection, Intramural Hematoma)
    • Quality: Abrupt, “tearing” or “ripping” pain; maximal intensity at onset.
    • Radiation: Often radiates to the back (interscapular area).
    • Risk Factors: Uncontrolled HTN, Bicuspid Aortic Valve, Marfan Syndrome, or Ehlers-Danlos.
    • Key Finding: Possible asymmetric BPs/pulses between arms.
  • Esophageal (GERD, Esophagitis, Diffuse Esophageal Spasm)
    • Quality: Substernal pain; may refer to the neck or back.
    • Triggers: Provoked by recumbent position (lying down) or post-prandial state.
    • Associated Symptoms: Bitter taste (regurgitation), dysphagia, or dyspepsia.
    • Relieving Factors: Nonexertional; relieved by antacids or H2 blockers/PPIs.
    • Note: Nitroglycerin can occasionally relieve Esophageal Spasm, often confusing it with CAD.
  • Chest Wall / Musculoskeletal (MSK)
    • Quality: Persistent, localized pain.
    • Triggers: Worse with movement, certain positions, or palpation (e.g., Costochondritis).
    • History: Often follows repetitive activity or heavy lifting.
    • Key Finding: Reproducible pain on palpation of the chest wall.