• Etiology/Pathophysiology
    • Inflammation of the costochondral or sternocostal junctions.
    • Usually idiopathic; associated with physical overuse, trauma, or recent viral URI.
    • Differentiate from Tietze Syndrome: Costochondritis has no palpable swelling, whereas Tietze Syndrome presents with localized swelling/edema.
  • Clinical Features
    • Chief Complaint: Sharp, aching, or pressure-like anterior chest wall pain.
    • Aggravating Factors: Deep inspiration, coughing, or movement of the upper body.
    • Physical Exam (Key Finding): Reproducible tenderness to palpation over the involved costochondral joints (most commonly ribs 2–5).
    • Absence of erythema, heat, or swelling.
  • Diagnostics
    • Clinical Diagnosis: Based on Hx and reproducible tenderness.
    • Rule Out ACS: In pts >35 years or with cardiac risk factors, must exclude Acute Coronary Syndrome (ACS) first.
      • ECG: Normal.
      • Troponins: Negative.
    • CXR: Generally normal; used to rule out bony pathology or pulmonary causes if Sx are atypical.
  • Treatment
    • Reassurance: Self-limiting condition.
    • Pharmacologic: NSAIDs (e.g., ibuprofen, naproxen) or Acetaminophen.
    • Refractory: Local anesthetic/steroid injection (rarely needed).
  • Differential Diagnosis
    • Acute Coronary Syndrome (MI/Unstable Angina): Pain is usually substernal, exertsional, not reproducible by palpation.
    • Tietze Syndrome: Palpable swelling + tenderness.
    • Pericarditis: Positional pain (relieved by leaning forward), friction rub, diffuse ST elevation.
    • Pulmonary Embolism: Dyspnea, hypoxia, tachycardia.