Agents
- Cisplatin
- Carboplatin
- Oxaliplatin
Mechanism
Cross-links between DNA strands → ↓ DNA replication
Indications
- Lymphomas
- Solid tumors
- Cervical cancer (cisplatin)
- Osteosarcoma (cisplatin)
Adverse effects
- Nephrotoxicity (may manifest as Fanconi syndrome)
- Neurotoxicity (including peripheral neuropathies)
- Ototoxicity