Associated conditions
- Hepatocellular carcinoma (HCC)
- Hepatoblastoma
- Yolk sac tumor (endodermal sinus tumor)
- Mixed germ cell tumor
- Ataxia-telangiectasia
Tip
- AFP is normally produced by the fetus → transient elevation of maternal AFP levels
- ↑ AFP: abdominal wall defects, neural tube defects
- ↓ AFP: associated with trisomy 21, 18, and 13