| Feature | Choriocarcinoma | Hydatidiform Mole | Teratoma |
|---|
| Nature | Malignant | Premalignant | Benign (usually) |
| Origin | Trophoblasts (often from molar pregnancy) | Trophoblasts (from abnormal fertilization) | Germ cells |
| Karyotype | Aneuploid (often derived from mole) | 46,XX (Complete) or 69,XXX/XXY (Partial) | 46,XX |
| Key Histo | Anaplastic trophoblasts, NO villi | Hydropic (swollen) villi | Mature tissue (hair, teeth, etc.) |
| β-hCG | Massively ↑ (>100k) | Massively ↑ (>100k, Complete) | Normal |
| Key Sx | Lung mets (hemoptysis, dyspnea) | Uterine size > dates, preeclampsia <20wks | Asymptomatic or ovarian torsion |
| Ultrasound | Solid uterine mass | ”Snowstorm” appearance (Complete) | Cyst with calcifications/fat |
| Treatment | Chemotherapy (Methotrexate) | Suction Curettage | Surgical Removal (Cystectomy) |