Epidemiology
Etiology
Pathophysiology
Clinical features
Immunocompetent patients
- > 90%: asymptomatic course
- < 10%: CMV mononucleosis
- Fever, malaise, myalgia/arthralgia, fatigue, headache
- Less common: sore throat, cervical lymphadenopathy, hepatomegaly, splenomegaly
- Differential diagnosis: infectious mononucleosis caused by EBV
Diagnostics
- Histology: Enlarged cells with large, eosinophilic intranuclear inclusions surrounded by a clear halo (“owl’s eye” appearance).
Treatment
- Preferred: ganciclovir or valganciclovir
- Alternatives: foscarnet, cidofovir