| Feature | Hodgkin Lymphoma (HL) | Non-Hodgkin Lymphoma (NHL) |
|---|
| Key Cell | Reed-Sternberg (“owl-eye”) | Malignant lymphocytes (B or T cell) |
| Spread | Contiguous (orderly, predictable) | Non-contiguous (disseminated) |
| Presentation | Localized, single node group (e.g., cervical, mediastinal) | Multiple peripheral nodes, extranodal common |
| ”B” Symptoms | Common (fever, night sweats, wt loss) | Less common |
| Age | Bimodal (20s, >50s) | Typically >50 years old |
| Prognosis | High cure rate | Variable; depends on subtype |
| Key Associations | EBV | EBV, HTLV-1, HHV-8; translocations (e.g., t(14;18), t(8;14)) |