Epidemiology

Etiology

Pathophysiology

Clinical features

Similar features like serotonin syndrome, but without neuromuscular findings (especially prominent clonus and lower limb rigidity/hyperreflexia)

Diagnostics

Treatment

• First-line: benzodiazepines
  • Shorter or intermediate-acting (e.g., oxazepam, lorazepam): Consider in patients with a slow metabolism (e.g., the elderly, those with liver failure).
  • Longer acting (e.g., chlordiazepoxide, diazepam): preferred in all other patients