Epidemiology

  • Peak incidence: 10–19 years of age

Etiology

  • Pathogenesis: Obstruction of the appendiceal lumen.
    • Adults: Fecalith (most common)
    • Children/Adolescents: Lymphoid hyperplasia (often post-viral infection)
    • Less common: tumor (carcinoid), foreign body, parasites
  • Obstruction → ↑ intraluminal pressure → venous congestion → ischemia → bacterial invasion → necrosis/perforation.

  • Anatomical positions of appendix
    • Retrocecal / Retrocolic (~65%): Behind the cecum or ascending colon. Most common variant.
    • Pelvic (~31%): Lies in the true pelvis, close to the rectouterine/rectovesical pouch. Second most common.
    • Subcecal (~2.3%): Lies inferior to the cecum.
    • Pre-ileal (~1%): Lies anterior to the terminal ileum.
    • Post-ileal / Retroileal (~0.4%): Lies posterior to the terminal ileum.

Pathophysiology


Clinical features

  • Migratory RLQ pain (begins as diffuse periumbilical pain, then localizes to McBurney point).
  • Anorexia (classic “hamburger sign”), nausea, vomiting.
  • Low-grade fever, mild tachycardia.
  • Peritoneal signs (signifies perforation/peritonitis):
    • Rebound tenderness, guarding, rigidity.
  • Diagnostic signs:
    • Rovsing sign: LLQ palpation causes RLQ pain.
    • Psoas sign: RLQ pain with passive extension of right hip (indicates retrocecal appendix). c
    • Obturator sign: RLQ pain with passive internal rotation of flexed right hip (indicates pelvic appendix).
    • McBurney point tenderness: Maximal tenderness 1/3 of the distance from the ASIS to the umbilicus.

Diagnostics

  • Primarily a clinical diagnosis; typical presentations in males do not require imaging before surgery.
  • Labs: ↑ WBC (leukocytosis with left shift). Beta-hCG in all females of childbearing age to rule out ectopic pregnancy.
  • Imaging (if Dx unclear):
    • CT abdomen/pelvis with contrast (preferred in adults): Shows thickened wall (>6 mm), target sign, appendiceal wall enhancement, and periappendiceal fat stranding.
    • Ultrasound or MRI (preferred in pregnant pts and children to avoid radiation).

Treatment


Special patient groups

Appendicitis in pregnant individuals

Clinical Features

  • Anatomical displacement: The growing gravid uterus displaces the appendix upward and outward (counterclockwise rotation).
  • Atypical pain location:
    • RLQ pain in the 1st trimester (similar to non-pregnant).
    • RUQ or right flank pain in the 3rd trimester as the appendix is displaced superiorly.
  • Nausea and vomiting: Present in majority of cases, but frequently dismissed as normal pregnancy-related symptoms (e.g., morning sickness).
  • Peritoneal signs: Guarding and rebound tenderness are often absent or diminished because the gravid uterus lifts the abdominal wall away from the inflamed appendix.
  • Alder sign: Pain does not shift when the pt is turned onto the left lateral decubitus position, pointing to an extrauterine etiology.

Management

  1. Surgical Intervention (First-line): Urgent laparoscopic appendectomy.
    • Performed in all trimesters. Laparoscopy is preferred over open surgery due to less post-op pain, faster recovery, and lower risk of fetal loss.
    • Open appendectomy is indicated if advanced gestational age (late 3rd trimester) limits laparoscopic visualization/access.
  2. Antibiotic Therapy: Broad-spectrum IV Abx (e.g., Cefoxitin, Cefotetan, or Ampicillin/Sulbactam) initiated immediately prior to surgery.
  3. Fetal Monitoring:
    • Pre-op and post-op FHT assessment.
    • Continuous tocodynamometry (contraction monitoring) if viable fetus (> 24 weeks gestation).