| Disorder | Osteoclast Activity | Osteoblast Activity | Mineralization | Key Associations |
|---|
| Osteoporosis | ↑ (Resorption) | ↓ (Formation) | Normal | Trabecular thinning, Normal Labs |
| Osteopetrosis | Dysfunctional (Defective resorption) | ↔ / ↑ | Normal | Thick bone, Carbonic Anhydrase II mut. |
| Osteomalacia / Rickets | ↑ (Due to 2° PTH) | ↑ (Reactive) | Defective | Unmineralized osteoid, soft bone, ↓ Vit D |
| Paget Disease | ↑↑ (Lytic Phase) | ↑↑ (Sclerotic Phase) | Normal | Mosaic pattern, woven bone, Isolated ↑ ALP |
| Osteitis Fibrosa Cystica | ↑↑ (PTH driven) | ↑ | Normal | Brown tumors, Subperiosteal thinning |