| Disorder | Diagnostic Features | Mutation |
|---|
| Chronic myelogenous leukemia | Constitutional symptoms (e.g., fatigue, weight loss, excessive sweating), splenomegaly & leukocytosis with marked left shift (e.g., myelocytes, metamyelocytes, band forms) | Philadelphia chromosome t(9:22), BCR-ABL fusion protein |
| Essential thrombocytosis | Hemorrhagic & thrombotic symptoms (e.g., easy bruising, microangiopathic occlusion), thrombocytosis & megakaryocytic hyperplasia | JAK2 |
| Polycythemia vera | Pruritus, erythromelalgia, splenomegaly, thrombotic complications, erythrocytosis & thrombocytosis | JAK2 |
| Primary myelofibrosis | Severe fatigue, splenomegaly (often causing early satiety/abdominal discomfort), hepatomegaly, anemia & bone marrow fibrosis | JAK2 |