Epidemiology

• Most common type of sex cord-stromal malignancy (�?90%)
• Peak age: 50�?5 years

Etiology

Pathophysiology

Clinical features

• Symptoms caused by estrogen and/or progesterone secretion
  • Adult subtype: menstrual irregularities (e.g., postmenopausal bleeding, endometrial hyperplasia with metrorrhagia)
  • Juvenile subtype: precocious puberty
• Breast tenderness
• Associated with increased risk of endometrial cancer

Diagnostics

Pathology

• Call-Exner bodies: granulosa cells arranged in clusters surrounding a central cavity with eosinophilic secretions, resembling primordial follicles

Treatment