Hard signs present: Skip imaging -> OR immediately.
Soft signs present or asymptomatic: Ankle-Brachial Index (ABI) or Arterial Pressure Index (API) for upper extremity.
Key Imaging: Plain radiography (X-ray) of the extremity to assess for concurrent fractures, retained projectiles/foreign bodies, or subfascial air.
Confirmatory/Gold Standard: CT Angiography (CTA).
Indicated if ABI/API < 0.9, abnormal distal pulses, or soft signs present.
Duplex US is an alternative if CTA is unavailable or contraindicated.
Differential Diagnostics
Compartment Syndrome: Diff by tense, “wood-like” extremity, pain out of proportion, and severe pain with passive muscle stretch. (May co-exist or develop after reperfusion).
Isolated Peripheral Nerve Injury: Diff by focal motor/sensory deficits (e.g., foot drop) but normal vascular assessment (ABI > 0.9, normal pulses).
Isolated Orthopedic Trauma: Diff by bony deformity, crepitus, and positive X-ray findings without vascular compromise.
Management
Stabilize (Primary Survey): ABCs. Control active hemorrhage with direct pressure. If direct pressure fails -> apply a tourniquet proximal to the injury.
Surgical (Hard Signs): Immediate surgical exploration in the OR. Do not delay for imaging.
Algorithmic Approach (Soft Signs / Asymptomatic):
Measure ABI/API.
If ABI/API < 0.9 -> CTA. (If CTA shows injury -> Surgery or endovascular repair).
If ABI/API ≥ 0.9 -> Serial physical exams + observation.
Adjunctive Care:
Update Tetanus prophylaxis.
IV Abx (e.g., Cefazolin) if there is an open fracture or gross contamination.
Fracture stabilization (splint/traction) if applicable.
eFAST Role: Quick bedside check for hemoperitoneum/pneumothorax, but negative FAST does NOT rule out hollow viscus, diaphragmatic, or retroperitoneal injury.
Acute Resuscitation & Medical Management:
Permissive Hypotension: Target SBP 80–90 mmHg (MAP ~65 mmHg) until surgical control (avoid if severe TBI).
Massive Transfusion Protocol (MTP): Early activation with a 1:1:1 ratio of PRBCs : FFP : Platelets.
Tranexamic Acid (TXA): Administer IV within 3 hours of injury.
Prophylaxis: Broad-spectrum IV antibiotics (e.g., Cefazolin + Metronidazole or Ampicillin-Sulbactam) + Tetanus toxoid ± TIG.
Surgical Strategy & Damage Control Surgery (DCS):
Triggered by the Lethal Triad: Hypothermia (< 35°C), Acidosis (pH < 7.2), and Coagulopathy.
Stage 1: Abbreviated laparotomy (stop hemorrhage, staple hollow-viscus leaks, pack 4 quadrants, leave abdomen open with negative-pressure dressing).
Stage 2: ICU resuscitation (rewarming, MTP correction of coagulopathy).
Stage 3: Definitive reconstruction and fascial closure in 24–48 hours.