• What it is / Why you do it
    • Large-bore venous access for:
      • Vasoactive meds (pressors, inotropes) — avoid peripheral extravasation
      • Hemodynamic monitoring (CVP, ScvO₂) (limited utility but testable)
      • Rapid infusion (trauma/hemorrhage) if no good peripheral access
      • High-osmolar/irritant infusions (TPN, chemo, hypertonic solutions)
      • Frequent blood draws
      • Hemodialysis/apheresis (needs dialysis catheter, not standard triple-lumen)

  • Common sites (pros/cons)
    • Internal jugular (IJ) (often US-guided)
      • Pros: Compressible (better if bleeding), good US visualization
      • Cons: Carotid puncture, pt discomfort/neck mobility issues
    • Subclavian
      • Pros: Lowest infection risk, comfortable for long-term
      • Cons: Not compressible → bad choice in coagulopathy; ↑ pneumothorax risk
    • Femoral
      • Pros: Fast during codes/trauma, avoids pneumothorax, easiest in shock
      • Cons: ↑ infection + thrombosis risk; limits ambulation

Exam move: If high bleeding risk/coagulopathy, prefer IJ or femoral (compressible), avoid subclavian.


  • Contraindications (practical, testable)
    • Absolute (rare)
      • Overlying infection/burn at insertion site
      • Venous thrombosis/occlusion of target vessel
    • Relative
      • Coagulopathy/therapeutic anticoagulation (esp subclavian)
      • Distorted anatomy (tumor, prior surgery/radiation)
      • Severe hypoxemia/PEEP dependence (pneumothorax could be catastrophic → avoid subclavian)

  • Technique essentials (high yield)
    • Ultrasound guidance: improves success, ↓ arterial puncture/pneumothorax (esp IJ/femoral)
    • Sterile technique: hand hygiene, cap/mask, sterile gown/gloves, full-body drape, chlorhexidine prep
    • Seldinger technique: needle → guidewire → dilator → catheter
    • Air embolism prevention
      • Pt supine/Trendelenburg (IJ/subclavian)
      • Occlusive dressings; clamp lumens; instruct pt not to inspire deeply during line manipulation

  • Confirming placement
    • IJ/Subclavian CVC: portable chest x-ray to confirm tip position + rule out pneumothorax (classic Step 2) c
    • US can confirm venous cannulation and detect immediate pneumothorax, but many exams still expect post-procedure CXR
    • Femoral: CXR not needed for pneumothorax; confirm function/aspiration/flush

  • Complications (recognize + next step)
    • Mechanical
      • Pneumothorax (subclavian > IJ)
        • Sx: sudden dyspnea, pleuritic CP, ↓ breath sounds
        • Tx: O₂; needle decompression if tension → chest tube
    • Arterial puncture (carotid/femoral)
      • Small needle puncture: remove + direct pressure
      • Large-bore/dilator in artery: leave in place + vascular surgery
    • Hematoma (esp anticoagulated)
    • Air embolism
      • Sx: acute resp distress, “mill wheel” murmur (classically)
      • Tx: Left lateral decubitus + Trendelenburg, 100% O₂
    • Arrhythmia (wire irritates RV) → pull back wire
    • Malposition (contralateral veins, azygos, RA) → reposition
    • Thrombotic
      • Upper extremity DVT/SVC syndrome (arm/neck swelling, collateral veins)
    • Infectious
      • CLABSI risk: femoral highest; subclavian lowest

  • Line infection approach (Step 2 algorithm)
    • Suspected CLABSI (fever/chills, no other source):
      • Draw blood cultures (often from line + peripheral) before abx
      • Start empiric IV abx if unstable/high risk
      • Remove catheter if:
        • Severe sepsis/hemodynamic instability
        • Purulence at site
        • Persistent bacteremia
        • S. aureus, Candida, Pseudomonas, or complicated infection
      • Consider catheter salvage only in select stable pts w/ low-virulence orgs + no complications

  • Which access is “best” in common scenarios
    • Code/CPR, crashing pt: femoral (fast, no pneumothorax)
    • Need lowest infection risk for longer use: subclavian (if no coagulopathy)
    • Coagulopathy: IJ (US-guided) or femoral; avoid subclavian
    • High ventilator settings/severe COPD: avoid subclavian if possible (pneumothorax risk)