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Epidemiology & Risk Factors
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90% viral etiology (Rhinovirus, Coronavirus, Influenza, RSV, Parainfluenza).
- Bacterial causes are rare (<10%) and include Bordetella pertussis, Mycoplasma pneumoniae, Chlamydia pneumoniae.
- Often preceded by a standard viral URI.
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Clinical Features
- Hallmark: Cough persisting > 5 days (typically lasts 1-3 weeks).
- Sputum production (clear, yellow, or green/purulent – purulence is due to sloughed epithelial cells, NOT necessarily bacterial infection).
- Wheezing or rhonchi that clear with coughing.
- Mild dyspnea.
- Negative findings: Usually lacks high fever, tachycardia, tachypnea, or focal lung examination findings (e.g., crackles, egophony).
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Diagnosis
- Initial/Screening: Primarily a clinical diagnosis.
- Key Labs/Imaging:
- CXR: Usually normal. Indicated only if pneumonia is suspected to rule out consolidation. Criteria for CXR: Abnormal vital signs (HR >100, RR >24, Temp >38°C/100.4°F) or focal consolidation signs on exam (rales, egophony, tactile fremitus).
- Respiratory viral panel (e.g., Influenza/COVID-19 swab) if in season and will change management.
- Confirmatory/Gold Standard: Clinical diagnosis; no routine confirmatory testing required.
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Differential Diagnostics
- Pneumonia: Diff by (+) high fever, focal crackles/rales, signs of consolidation (dullness to percussion, (+) egophony), and infiltrates on CXR.
- Asthma Exacerbation: Diff by hx of recurrent wheezing/atopy, reversible airflow obstruction on spirometry.
- Pertussis: Diff by paroxysmal cough, inspiratory “whoop,” post-tussive emesis, lack of routine vaccinations.
- Post-Nasal Drip / GERD / ACE-I Cough: Diff by chronic cough (>8 weeks) and lacking preceding acute URI symptoms.
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Management
- First-line (Supportive): Symptom relief.
- NSAIDs/Acetaminophen for malaise.
- Antitussives (e.g., dextromethorphan, guaifenesin) for cough suppression (limited efficacy but commonly used).
- Targeted Symptom Relief: Inhaled bronchodilators (albuterol) only if active wheezing/underlying bronchospasm is present.
- Antibiotics are NOT indicated: High-yield NBME concept. Do not prescribe Abx even if sputum is purulent/green, unless B. pertussis is confirmed or strongly suspected (then macrolides).
- First-line (Supportive): Symptom relief.
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Complications
- Post-viral cough (hyperreactive airways persisting weeks to months).
- Bronchospasm.
- Rare progression to secondary bacterial pneumonia.