Huntington disease

Epidemiology


Etiology


Pathophysiology

Molecular and cellular changes lead to neuronal loss and gliosis in the striatum (particularly in the caudate nucleus)

Mnemonic

Pasted image 20240328162707.png


Clinical features

Tip

Chorea characterizes the early stages of the disease while hypokinetic/akinetic symptoms may dominate later on. Dementia, depression, and behavioral disorders are common in advanced stages.


Diagnostics

Differential diagnostics


Ballismus

Treatment