- Classification: based on radiological findings
- Osteoblastic metastasis
- New bone formation by osteoblasts outweighs osteolytic processes → increase in radiographic density
- They secrete Endothelin-1 (ET-1)
- Examples: prostate cancer, small cell lung cancer
- Osteolytic metastasis
- Osteolytic processes outweigh new bone formation → decrease in radiographic density
- They secrete PTHrP
- Examples: multiple myeloma, thyroid cancer, kidney cancer, melanoma, non-small cell lung cancer
- Mixed metastasis: e.g., breast cancer, gastrointestinal cancer