Liver zones
- Zone 1: The periportal zone
- Is best oxygenated and, therefore, is most resistant to ischemia.
- Affected first in viral hepatitis and toxic substance ingestion, e.g., cocaine.
- Zone 2: intermediate zone (liver): affected in yellow fever
Mnemonic
Zone II is affected in yellow fever.
- Zone 3: pericentral vein/centrilobular zone
- The least oxygenated zone, and thus most susceptible to ischemia
- Most sensitive to metabolic toxins (e.g., ethanol, CCl4, halothane, rifampin, acetaminophen)
- Site of alcoholic hepatitis
- Has the highest amount of cytochrome P-450
