Halothane hepatitis
- Pathophysiology: An immunoreaction to hepatic halothane metabolites is suspected.
- Clinical features
- Occurs 2 days to 3 weeks after halothane exposure
- Signs of acute hepatitis (e.g., jaundice, fever, vomiting, hepatomegaly)
- Rash, arthralgias
- Diagnostics: diagnosis of exclusion
- Possible laboratory findings: ↑ eosinophils, ↑ serum transaminases , ↑ bilirubin, ↑ alkaline phosphatase
- Biopsy shows massive centrilobular hepatic necrosis