Definition
A cutaneous T-cell lymphoma with leukemic dissemination of mutated T cells
Epidemiology
advanced form of mycosis fungoides or arise de novo
Clinical features
- Systemic skin lesions
- Erythroderma accompanied by palmar and plantar hyperkeratosis
- Intense pruritus
- Generalized lymphadenopathy
Diagnostics
- Peripheral Blood Smear:
- Sézary Cells: Atypical T-cells with cerebriform nuclei (brain-like, convoluted nuclear appearance). High-yield buzzword. t
- Sézary Cells: Atypical T-cells with cerebriform nuclei (brain-like, convoluted nuclear appearance). High-yield buzzword. t