| Chronic myelogenous leukemia |
Constitutional symptoms (e.g., fatigue, weight loss, excessive sweating), splenomegaly & leukocytosis with marked left shift (e.g., myelocytes, metamyelocytes, band forms) |
Philadelphia chromosome t(9:22), BCR-ABL fusion protein |
| Essential thrombocytosis |
Hemorrhagic & thrombotic symptoms (e.g., easy bruising, microangiopathic occlusion), thrombocytosis & megakaryocytic hyperplasia |
JAK2 |
| Polycythemia vera |
Pruritus, erythromelalgia, splenomegaly, thrombotic complications, erythrocytosis & thrombocytosis |
JAK2 |
| Primary myelofibrosis |
Severe fatigue, splenomegaly (often causing early satiety/abdominal discomfort), hepatomegaly, anemia & bone marrow fibrosis |
JAK2 |