- Platelet disorder (diseases of Primary Hemostasis)
- Small and superficial
- Mucocutaneous bleed with minor trauma, small ecchymoses or petechiae
- Normal PT/PTT t
- Coagulation factors disorder (diseases of Secondary Hemostasis)
- Large and deep
- Large hematomas, muscle bleed or hemarthrosis
- Increased PT
- Factor VII deficiency
- Monitoring of vitamin K antagonist therapy (INR)
- Increased aPTT
- Hemophilia
- Severe cases of von Willebrand disease
- SLE (if lupus anticoagulant is present)
- Antiphospholipid syndrome (paradoxically)
- Monitoring of unfractionated heparin (UFH) therapy
- Increased PT and aPTT
- Vitamin K deficiency
- DIC