| Source |
Derived from arachidonic acid |
Derived from arachidonic acid |
| Function |
Involved in various physiological processes, including inflammation, pain, and regulation of blood flow |
Primarily functions as a vasodilator and inhibits platelet aggregation |
| Types |
Several types (e.g., PGE2, PGF2α) |
One main type: PGI2 |
| Receptors |
Multiple receptors (e.g., EP, FP, DP) |
Specific receptors (IP receptors) |
| Effects on Blood Vessels |
Can cause vasodilation or vasoconstriction depending on the type |
Causes vasodilation |
| Effects on Platelets |
Can stimulate platelet aggregation (e.g., thromboxane A2) |
Inhibits platelet aggregation |
| Role in Inflammation |
Key mediators in the inflammatory response |
Less direct role in inflammation |
| Half-life |
Short half-life (minutes) |
Short half-life (minutes) |
| Clinical Relevance |
Used in various treatments (e.g., labor induction, gastric protection) |
Used in treating pulmonary hypertension and cardiovascular diseases |
